Current Trends in Tuberculosis Pharmacotherapy: Availability of Essential Medicines
DOI:
https://doi.org/10.53933/sspmpm.v5i2.188Keywords:
tuberculosis, pharmacotherapy, BPaL (Bedaquiline, Pretomanid, and Linezolid), multidrug-resistant tuberculosis, diagnostics, artificial intelligence, legislation, financing, preventionAbstract
The article analyzes current trends in tuberculosis pharmacotherapy and the availability of essential medicines. The introduction of short-term treatment regimens, in particular BPaL (Bedaquiline, Pretomanid, and Linezolid), significantly reduces the duration of multidrug-resistant tuberculosis therapy and increases its effectiveness. Expanding diagnostic capabilities, especially the use of artificial intelligence, contributes to improving the detection of the disease. Analysis of legislative initiatives indicates improved access to treatment, but financing remains an important challenge, especially under conditions of martial law. The dynamics of the incidence demonstrates an increase in the number of tuberculosis cases, which requires strengthening preventive measures and screening programs. The prospects for further research and the need to increase state funding to reduce dependence on international donors are highlighted.
Additionally, the growing emphasis on patient-centered care is reshaping programmatic management of tuberculosis. At the same time, integration of tuberculosis services with HIV and diabetes screening is becoming standard practice, reflecting the high prevalence of comorbidities. To meet the WHO End Tuberculosis Strategy milestones for 2030, policymakers must prioritize sustained domestic investment, ensure uninterrupted supply chains, and expand community-based education to address stigma and the social determinants driving transmission.
References
Shapovalova V. Innovative approaches to medical and pharmaceutical care, pharmacotherapy, and availability of pharmaceutical supplies for Tuberculosis patients in wartime. SSP Modern Pharmacy and Medicine. 2025. Vol.5. No.1. P.1-17. URL: https://doi.org/10.53933/sspmpm.v5i1.170 DOI: https://doi.org/10.53933/sspmpm.v5i1.170
Shepeleva A. How war worsens the epidemic situation in Ukraine. DW. 14.06.2022. URL: https://www.dw.com/uk/tuberkuloz-vil-ta-kholera-yaki-ryzyky-nese-viina-dlia-zdorovia-ukraintsiv/a-62092825
Osyntseva A., Shapovalov V. Management and marketing of circulation of first-line antituberculosis medicines: use of innovative research technologies. SSP Modern Pharmacy and Medicine. 2023. Vol.3. No.4. P.1-13. URL: https://doi.org/10.53933/sspmpm.v3i4.114
Osyntseva A. Administration of drugs for pharmacotherapy of Tuberculosis according to GSP requirements. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.2. P.1-17. URL: https://doi.org/10.53933/sspmpm.v4i2.140 DOI: https://doi.org/10.53933/sspmpm.v4i2.140
Vovk D., Puhach O., Bachynska L. et al. The Role of the general practitioner-family doctor in the pharmacotherapy of Tuberculosis during the war. SSP Modern Pharmacy and Medicine. 2023. Vo.3. No.3. P.1-7. URL: https://doi.org/10.53933/sspmpm.v3i3.102 DOI: https://doi.org/10.53933/sspmpm.v3i3.102
Tuberculosis deaths and disease increase during the COVID-19 pandemic. WHO. 27.10.2022. URL: https://www.who.int/news/item/27-10-2022-tuberculosis-deaths-and-disease-increase-during-the-covid-19-pandemic
Tuberculosis and war: how Ukraine confronts two threats at the same time. Center for Public Health. 07.06.2022. URL: https://phc.org.ua/news/tuberkuloz-i-viyna-yak-ukraina-protistoit-dvom-zagrozam-odnochasno
Global Tuberculosis Report 2022. World Health Organization. 2022. URL: https://www.who.int/publications/i/item/9789240061729](https://www.who.int/publications/i/item/9789240061729.
Weekly report on public health risks. Public Health Center of Ukraine. 2023. URL: https://phc.org.ua/sites/default/files/users/user90/risk_2023_50.pdf
Shapovalova V. An Innovative multidisciplinary study of the availability of coronavirus vaccines in the world. SSP Modern Pharmacy and Medicine. 2022. Vol.2. Nо.2. P.1-17 URL: https://doi.org/10.53933/sspmpm.v2i2.45. DOI: https://doi.org/10.53933/sspmpm.v2i2.45
Shapovalova V. Musculoskeletal health systematic review: clinical and pharmacological, organizational and legal, administration and pharmaceutical management aspects. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.2. P.1-12. URL: https://doi.org/10.53933/sspmpm.v4i2.134 DOI: https://doi.org/10.53933/sspmpm.v4i2.134
On approval of the sixteenth edition of the State Formulary of Medicines and ensuring its availability: Order of the Ministry of Health of Ukraine dated 12.03.2024 No. 418. URL: https://moz.gov.ua/article/ministry-mandates/nakaz-moz-ukraini-vid-12032024--418-pro-zatverdzhennja-shistnadcjatogo-vipusku-derzhavnogo-formuljara-likarskih-zasobiv-ta-zabezpechennja-jogo-dostupnosti
Shapovalova V. Forensic and pharmaceutical risks in the organization of pharmacotherapy of covid, post-covid and long-covid disorders. COVID-19 and vaccination practice standards. SSP Modern Pharmacy and Medicine. 2022. Vol. 2. No. 4. P. 1–24. URL: https://doi.org/10.53933/sspmpm.v2i4.69 DOI: https://doi.org/10.53933/sspmpm.v2i4.69
Osyntseva A. The Potential of Vitamin D in Tuberculosis Pharmacotherapy: Retrospective, Marketing Review, and Application Prospects. SSP Modern Pharmacy and Medicine. 2025. Vol.5. No.1. P.1–15. URL: https://doi.org/10.53933/sspmpm.v5i1.172 DOI: https://doi.org/10.53933/sspmpm.v5i1.172
Osyntseva, A. Use of B Vitamins in Pharmacotherapy of Tuberculosis: Retrospective and Marketing Analysis. SSP Modern Pharmacy and Medicine. 2024. Vol. 4. No. 3. P. 1–26. https://doi.org/10.53933/sspmpm.v4i3.154 DOI: https://doi.org/10.53933/sspmpm.v4i3.154
Osyntseva A. Use of Vitamins in Pharmacotherapy of Tuberculosis: retrospective and marketing analysis. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.4. P.1–15. URL: https://doi.org/10.53933/sspmpm.v4i4.164 DOI: https://doi.org/10.53933/sspmpm.v4i4.164
Ganmaa D., Uyanga B., Zhou X. et al. Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease. N Engl J Med. 2020. Vol. 383. Iss. 4. P.359–368. Doi: 10.1056/NEJMoa1915176. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476371/ DOI: https://doi.org/10.1056/NEJMoa1915176
Official statistics of the World Health Organization. Ministry of Health of Ukraine. January 12, 2024. URL: https://moz.gov.ua/article/news/358-ukrainciv-projshli-bezoplatne-likuvannja-likarsko-stijkogo-tuberkulozu-za-novitnoju-shemoju-bpal
National regulatory legal acts regulating the system of diagnostics, treatment and prevention of tuberculosis in Ukraine. Ministry of Health of Ukraine. January 12, 2024. URL: https://moz.gov.ua/article/news/verhovna-rada-uhvalila-zakon-pro-podolannja-tuberkulozu-v-ukraini
Ukraine will use artificial intelligence for tuberculosis diagnostics. Ukrinform. 19.02.2024. URL: https://www.ukrinform.ua/rubric-health/3829318-v-ukraini-zastosovuvatimut-si-dla-diagnostiki-tuberkulozu.html
Tuberculosis deaths and disease increase during the COVID-19 pandemic. WHO. 27.10.2022. URL: https://www.who.int/news/item/27-10-2022-tuberculosis-deaths-and-disease-increase-during-the-covid-19-pandemic
358 Ukrainians received free treatment for drug-resistant tuberculosis under the new BPaL scheme. Ministry of Health of Ukraine. 12.01.2024. URL: https://moz.gov.ua/article/news/358-ukrainciv-projshli-bezoplatne-likuvannja-likarsko-stijkogo-tuberkulozu-za-novitnoju-shemoju-bpal.
Ukraine will use artificial intelligence to diagnose tuberculosis. Ukrinform. 19.02.2024. URL: https://www.ukrinform.ua/rubric-health/3829318-v-ukraini-zastosovuvatimut-si-dla-diagnostiki-tuberkulozu.html
The Verkhovna Rada adopted the Law on Overcoming Tuberculosis in Ukraine. Ministry of Health of Ukraine. 17.07.2023. URL: https://moz.gov.ua/article/news/verhovna-rada-uhvalila-zakon-pro-podolannja-tuberkulozu-v-ukraini
Tuberculosis treatment: a new short-term BPaL scheme has been introduced in Ukraine. Ministry of Health of Ukraine. 2024. URL: https://moz.gov.ua/article/news/likuvannja-tuberkulozu-v-ukraini-vprovadzeno-novu-korotkostrokovu-shemu-bpal
Due to the COVID-19 pandemic, tuberculosis mortality has increased in the world. WHO. URL: https://newsyou.info/iz-za-pandemii-covid-19-v-mire-uvelichilas-smertnost-ot-tuberkuleza-voz
Osyntseva A., Shapovalov V. Management and marketing of circulation of first-line antituberculosis medicines: use of innovative research technologies. SSP Modern Pharmacy and Medicine. 2023. Vol.3. No.4. P.1-13. URL: https://doi.org/10.53933/sspmpm.v3i4.114 DOI: https://doi.org/10.53933/sspmpm.v3i4.114
Osyntseva A. Tuberculosis: Pharmacognosy, Medicinal Plant Raw Materials, Medicinal Plants, Phytotherapy. SSP Modern Pharmacy and Medicine. 2024. Vol. 4 No. 1 Р.1-10. DOI: https://doi.org/10.53933/sspmpm.v4i1.130. DOI: https://doi.org/10.53933/sspmpm.v4i1.130
Shapovalova V. Administration, marketing, pharmacotherapy of medicines in Neuro-Oncology. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.4. P.1-12. URL: https://doi.org/10.53933/sspmpm.v4i4.161 DOI: https://doi.org/10.53933/sspmpm.v4i4.161
Nevzghoda O., Osyntseva A., Shapovalov V. et al. Antitussive codeine medicines in Ukraine: clinical and pharmacological, marketing, regulatory aspects, and forecasts. Annals of Mechnikov’s Institute. 2025. No.1. P.33–45. URL: https://doi.org/10.5281/zenodo.15011812
Shapovalov V., Zakalyk H., Gubaryeva O. Interdisciplinary study on the peculiarities of preservig the mental health of minors and youth in conditions of martial law. SSP Modern Law and Practice. 2025. Vol.5. No.1. P.1-24. URL: https://doi.org/10.53933/sspmlp.v5i1.171 DOI: https://doi.org/10.53933/sspmlp.v5i1.171
Shapovalova V. Post-Traumatic Stress Disorder: administration, clinical and pharmacological, organizational and legal, pharmaceutical management, recent case studies. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.1. P.1-8. URL: https://doi.org/10.53933/sspmpm.v4i1.123 DOI: https://doi.org/10.53933/sspmpm.v4i1.123
Shapovalov V., Veits O., Panchenko O. et al. Pharmacy and Dentistry: a multidisciplinary study of the risks of circulation of medicinal products. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.1. P.1-11. URL: https://doi.org/10.53933/sspmpm.v4i1.132 DOI: https://doi.org/10.53933/sspmpm.v4i1.132
Shapovalov V., Derkach A. Marketing analysis and availability of drugs with ATC Code N07BB: current trends. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.4. P.1-10. URL: https://doi.org/10.53933/sspmpm.v4i4.167 DOI: https://doi.org/10.53933/sspmpm.v4i4.167
Shapovalova V. (2025). Human Metapneumovirus: Modern Challenges for Medicine and Pharmaceutics. SSP Modern Pharmacy and Medicine. Vol.5. No.1. P.1-14. URL: https://doi.org/10.53933/sspmpm.v5i2.180 DOI: https://doi.org/10.53933/sspmpm.v5i2.180
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Alina Osyntseva
This work is licensed under a Creative Commons Attribution 4.0 International License.
